Author ' s response to reviews Haploinsufficiency for BRCA 1 is associated with normal levels of

Author ' s response to reviews Title : Expression of estrogen receptor beta in the breast cancer cells of BRCA 1 mutation carriers

P-168: Evaluating The Raelationship between Infertility and Nutrition

Background: Infertility is an emotional crisis with physical economic and psychosocial challenge because it interferes with all personal life aspects. Infertility can be due to many reasons Many hypotheses have been proposed to explain this including issues of genetics, physiology, nutrition and management, Consuming vegetable protein (soy) instead of carbohydrates or animal protein is associat...

Author ' s response to reviews Title : Lympho - Vascular Invasion in BRCA related Breast Cancer compared to

Accelerated geroncogenesis in hereditary breast-ovarian cancer syndrome

The geroncogenesis hypothesis postulates that the decline in metabolic cellular health that occurs naturally with aging drives a "field effect" predisposing normal tissues for cancer development. We propose that mutations in the cancer susceptibility genes BRCA1/2 might trigger "accelerated geroncogenesis" in breast and ovarian epithelia. By speeding up the rate at which the metabolic threshold...

Increased progesterone receptor expression in benign epithelium of BRCA1-related breast cancers.

The study of pathologically normal breast epithelium of BRCA mutation carriers may yield insights into the early natural history of breast tumorigenesis. Hormone receptor expression was assessed in 24 cases of invasive breast cancer associated with a mutation in BRCA1 (n = 15) or BRCA2 (n = 9) and in 39 sporadic cases matched for patient age and tumor hormone receptor status. Expression of prog...